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Image Search Results
Journal: Nature Communications
Article Title: Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II
doi: 10.1038/s41467-018-06811-z
Figure Lengend Snippet: CRISPR-Cas9 screen identifies RBX1 as an essential gene for 17p loss prostate cancer cells. a Schematic illustration of CRISPR screening procedure in the isogenic pair of DU145 cells. b Box plots showing the distribution of sgRNA frequencies at different time points. c Overlapping of essential genes from this screen and from the previous reports. d Frequency histograms of enriched or depleted sgRNAs. POLR2A and EIF6 are two representatives of common essential genes. RBX1 and GTF2H1 are representatives of selective essential genes in the context of 17p loss
Article Snippet: The CRISPR-Cas9 screen was performed using the
Techniques: CRISPR